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Femmenessence®: Clinically Proven to Support Women's Hormonal Health

Femmenessence MacaPause® is truly unique. It’s one of the few natural products with extensive scientific and clinical research backing it, including studies on the exact ingredient we use - Maca-GO®. These studies, including pharmacology and toxicology studies, as well as three double-blind placebo controlled human clinical trials, have all been published in respected international medical journals.

What makes Femmenessence MacaPause® so special?  It's the first natural product shown in published clinical trials to have statistically significant effects on hormones in postmenopausal women. This powerful impact on hormones doesn’t just address common symptoms like hot flashes and night sweats—it goes deeper, supporting heart, bone and mental health, areas where hormones play a vital role for postmenopausal women.

By choosing Femmenessence MacaPause, you’re supporting:

• Normal hormone balance*
• Hot flashes and night sweats*
• Dryness and lack of desire*
• Balanced mood*
• Healthy energy levels*
• Improved sleep*
• Heart health*
• Bone health*
• Brain health*
• Healthy body weight*
• Hair, skin and nails*

Not only does Femmenessence work for all symptoms, but it has one of the highest success rates among natural products for reducing postmenopausal symptoms—84% in clinical trials.  And since those studies, we’ve seen that success rate increase to 95% when our customers receive personalized guidance from our Medical Team. By offering tailored advice on dosing, hydration and other diet and lifestyle factors, we help you get the most from Femmenessence.

What’s even more remarkable is how quickly Femmenessence works. In our clinical trials, women reported relief as fast as 2 days and up to 8 weeks, with most experiencing results in just 21 days, which is within their first box.**

But perhaps the most groundbreaking aspect of Femmenessence is how it works. Unlike other options that introduce plant or synthetic hormones into the body, Femmenessence addresses the root cause of hormonal imbalance by nourishing the Hypothalamus-Pituitary-Thyroid-Adrenal-Ovarian (HPTAO) axis. This axis is responsible for regulating the endocrine system, and supporting your body’s own hormone production, to restore your natural balance and harmony.

In our clinical trials, this approach led to positive impacts on key hormones, including:

• Estradiol*
• Progesterone*
• Thyroid*
• Adrenals*
• Cortisol*
• FSH (Follicle Stimulating Hormone)*

Estradiol

As shown in this graph, Femmenessence supports the body’s natural production of estradiol, unlike the placebo group which saw no statistically significant change. What’s especially fascinating is how Femmenessence helps the body reach an optimal estradiol level for postmenopausal women, and once this ideal level is reached, the production naturally plateaus, rather than continually increasing to levels of a young woman.

The average estradiol levels (measured in picograms per milliliter, or pg/mL) fluctuate throughout the menstrual cycle. Functional Health provides a more precise breakdown based on the different phases of the cycle, using Quest Diagnostics data:

• Follicular Phase: 19-144 pg/mL
• Mid-Cycle (Ovulation): 64-357 pg/mL
• Luteal Phase: 56-214 pg/mL
• Postmenopause: ≤ 31 pg/mL (significantly lower after menopause due to the cessation of ovarian function)

Note: There is no established pre-pubertal reference range using this assay.

As shown  in the graph above, Femmenessence reduced the body’s own production of FSH, unlike the placebo group, which saw no statistically significant change. What’s particularly interesting is how Femmenessence improves FSH levels while not changing them to the level of a premenopausal woman. 

FSH (Follicle Stimulating Hormone)

FSH is responsible for the release of an egg at the end of a woman’s cycle, but as we age, this process becomes more challenging, leading to higher FSH levels. In fact, a woman is often considered postmenopausal when her FSH levels exceed 30 IU.

The average levels of Follicle Stimulating Hormone (FSH) fluctuate throughout the menstrual cycle and reproductive stages. Functional Health provides a more precise breakdown based on different phases of the cycle, using Quest Diagnostics data:

• Follicular Phase: 2.5-10.2 mIU/mL
• Mid-Cycle (Ovulation): 3.1-17.7 mIU/mL
• Luteal Phase: 1.5-9.1 mIU/mL
• Postmenopause: 23.0-116.3 mIU/mL (after menopause, FSH levels increase significantly due to the cessation of ovarian function)

Note: No reference ranges have been established for individuals under 18 years old using this assay.

As shown  in the graph above, Femmenessence reduced the body’s own production of FSH, unlike the placebo group, which saw no statistically significant change. What’s particularly interesting is how Femmenessence improves FSH levels while not changing them to the level of a premenopausal woman. 

Scientific Gold Standards

In our clinical trials,  we used Kupperman’s Menopausal Index and Greene’s Menopausal Score, the scientific gold standards for assessing menopausal symptoms, to accurately compare Femmenessence to other products. One of the most interesting aspects of our research involved a placebo cross-over method. In this study, women began taking Femmenessence and saw a significant reduction in symptoms within two months. Then (without their knowledge), they were then switched to a placebo, and their symptoms worsened in the third month. When they unknowingly switched back to Femmenessence, their symptoms improved dramatically once again. This clearly demonstrated that Femmenessence was responsible for the significant improvements in their menopausal symptoms.

Heart Health 

Estrogen and progesterone play vital roles in heart health due to their function in the body. Estrogen helps increase HDL (the “good” cholesterol), reduce LDL (the “bad” cholesterol), and maintain the elasticity of arteries. Progesterone, often called the “relaxing hormone”,  protects arteries from spasms, especially during  a heart attack. 

In our double-blind, placebo cross-over clinical trials, Femmenessence supported healthy hormone levels, and over 3-4 months, showed the following benefits:

• Balanced HDL, LDL and triglycerides*
• Supported blood pressure within a normal range*
• Supported a healthy body weight*
• Helped maintain balanced blood sugar levels (insulin – glucagon)*

Mental Health

Hormones and neurotransmitters act as messengers within the brain and body, influencing mood, memory, and overall function. If your body struggles to produce enough of these messengers or if their pathways are disrupted, it can impact your mental health.

• Femmenessence uniquely supports both by providing essential amino acids that are the building blocks to produce both hormones and neurotransmitters*
• It also supports estrogen, which improves the connections and communication between neurons and cells*
• Additionally, Femmenessence helps maintain healthy cortisol levels, reducing stress and promoting better sleep patterns.*

Bone Health

• Femmenessence supports estrogen, which plays a key role in reducing bone loss by limiting the activity of osteoclast cells (cells that break down bone).*
• It also supports progesterone and testosterone, which contribute to new bone growth by activating osteoblast cells (cells that build bone).*
• Femmenessence promotes better absorption of essential minerals, like calcium and iron, supporting overall bone health. *
• In our clinical trials, after 4 months of taking Femmenessence, women experienced measurable improvements in their bone density, specifically in both the outer (cortical) and inner (subcortical) layers of their bones. The improvements in Z and T scores suggest stronger, healthier bones, indicating that Femmenessence may help reduce bone loss and promote new bone growth, important factors in managing bone health, particularly after menopause. 

Hair, Skin and Nails

Our hair, skin, and nails are deeply affected by hormonal changes, especially during peri- and post-menopause. The balance of hormones like androgens (male-type hormones) and thyroid function plays a key role in maintaining hair growth and skin elasticity. When this balance is disrupted, it can lead to hair thinning, dry or sagging skin, and brittle nails. In addition, without proper iron levels, many women find it difficult to respond to hair and skin treatments.

Femmenessence works to support this delicate balance. In our clinical trials, it was shown to:

• Support thyroid function, essential for hair and skin health*
• Improve iron absorption, vital for hair growth and strength*
• Balance androgen levels, which can reduce hair loss and acne*
• Support a healthy stress response, improving overall well-being*

Many women and clinicians have reported noticeable improvements in hair retention (less shedding), clearer complexions, and stronger nails after using Femmenessence.

Clinical Case Report

Hot flashes are a common concern during menopause, often impacting sleep, mood, and overall quality of life. This case report highlights the effectiveness and safety of Femmenessence (Lepidium peruvianum) for managing menopausal symptoms. A 32-year-old woman experienced hot flashes, night sweats, anxiety, and mood changes after a hysterectomy and oophorectomy. With a personalized nutrition plan, Femmenessence supplementation, and lifestyle adjustments, she saw significant improvements. In just two months, her hot flashes and anxiety were resolved, and her mood and sleep improved. This case demonstrates how Femmenessence, combined with targeted dietary changes, can safely and effectively reduce menopausal symptoms.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.