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Published Clinical Research Articles


Femmenessence Post Menopause

Maca-GO® as referenced in all the below medical journal publications, is a Symphony Natural Health proprietary ingredient and only available in our products. Maca-GO® is the sole ingredient in Femmenessence MacaPause® and is a proprietary combination of the different phenotypes of the herb maca (Lepidium peruvianum) specifically for hormone balance in women. Maca-GO® is sourced from our organic farms in Peru and then goes through our proprietary, 100% natural, manufacturing processes that is GMP, Organic and Kosher certified. This process concentrates the full spectrum of active ingredients and maximizes the bioavailability.

Maca-GO® is the ONLY clinically proven natural product that has demonstrated statistically significant effects on hormones in peri and post menopausal women. Our clinical trials also demonstrated that Maca-GO® has the highest success rate (84%) of any herbal product in the world in reducing menopausal symptoms in postmenopausal women as well as benefits for heart, bone and mental health.

Articles

Maca-GO White Paper – Clinical Effects of a Proprietary, Standardized, Concentrated, Organic Lepidium peruvianum Formulation (Maca-GO) as an Alternative to HRT by Ronald Carter, M.D.

Hormone-balancing and Pharmacological Effects of Therapeutic Doses of Lepidium peruvianum (Maca-GO) in Postmenopausal Women.
Menopause. 2005; 12 (6): 813.

Pre-Gelatinised Maca (Maca-GO) (Lepidium peruvianum Chacon) As Non-Hormonal Herbal Remedy To Reduce Menopausal Symptoms In Pre- And Postmenopausal Women.
Basic Clinical Pharmacology and Toxicology. Vol. 97, Supp l (1): 48.

Use of Gelatinized Maca (Maca-GO) (Lepidium peruvianum) in Early Postmenopausal Women a Pilot Study.

International Journal of Biomedical Science. 1 (1): 33-45.

Short and Long-Term Physiological Responses of Male and Female Rats to Two Dietary levels of Pre-Gelatinized Maca (Maca-GO) (Lepidium peruvianum Chacon).

International Journal of Biomedical Science. 1 (2): 13-28.

Hormone-balancing Effect of Pre-Gelatinized Organic Maca (Maca-GO) {Lepidium peruvianum Chacon): (Part I.) Biochemical and Pharmacodynamic Study on Maca using Clinical Laboratory Model on Ovariectomized Rats.

International Journal of Biomedical Science 2006: Vol. 2, No. 3. 100.

Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Maca-GO) (Lepidium peruvianum Chacon): (II) Physiological & symptomatic responses of early-postmenopausal women to standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical Study.

International Journal of Biomedical Science, Dec. 2006: vol. 2 no. 4, 360 – 374.

Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Maca-GO) (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient study.

International Journal of Biomedical Science., Dec. 2006: vol. 2 no. 4, 375 – 394.

Peruvian Maca: Two scientific names Lepidium meyenii Walpers and Lepidium peruvianum Chacon – Are they Phytochemically Synonymous?

Int. J. Biomed. Sci. 2015; 11 (1): 1. (Meissner HO, Mscisz A, Kedzia B, Pisulewski P, et al.)

Peruvian Maca (Lepidium peruvianum): (I) Phytochemical and genetic differences in three Maca phenotypes.

Int. J. Biomed. Sci. 2015; 11 (3): 131. (Meissner HO, Mscisz A, Mrozikiewicz M, et al.)

Peruvian Maca (Lepidium peruvianum): (II) Phytochemical Profiles of Four Prime Maca Phenotypes Grown in Two Geographically-Distant Locations.

Int J Biomed Sci vol. 12 no. 1 March 2016. (Meissner HO, Mscisz A, Piatkowska E, et al.)

Peruvian Maca (Lepidium peruvianum) - III: The Effects of Cultivation Altitude on Phytochemical and Genetic Differences in the Four Prime Maca Phenotypes.

Int J Biomed Sci vol. 13 no. 2 June 2017. (Meissner HO, Mscisz A, Baraniak M, et al.)


Femmenessence Perimenopause

Maca-GO® as referenced in all the below medical journal publications, is a Symphony Natural Health proprietary ingredient and only available in our products. Femmenessence MacaLife®, our product for perimenopausal women, is made up of 25% Maca-GO® and 75% one other maca phenotype that we have seen in research is ideal to reduce menopausal symptoms.

 

Maca-GO® is the ONLY clinically proven natural product that has demonstrated statistically significant effects on hormones in peri and post menopausal women. Our clinical trials also demonstrated that Maca-GO® has the highest success rates (74-82%) in reducing menopausal symptoms in perimenopausal women as well as benefits for heart and mental health.

Article

Maca-GO White Paper – Clinical Effects of a Proprietary, Standardized, Concentrated, Organic Lepidium peruvianum Formulation (Maca-GO) as an Alternative to HRT by Ronald Carter, M.D.

Pre-Gelatinised Maca (Maca-GO) (Lepidium peruvianum Chacon) As Non-Hormonal Herbal Remedy To Reduce Menopausal Symptoms In Pre- And Postmenopausal Women.

Basic Clinical Pharmacology Toxicology. Vol. 97, Supp l (1): 48.

Short and Long-Term Physiological Responses of Male and Female Rats to Two Dietary levels of Pre-Gelatinized Maca (Maca-GO) (Lepidium peruvianum Chacon).

International Journal of Biomedical Science. 1 (2): 13-28.

Therapeutic effect of Lepidium peruvianum Chacon (Maca-GO) used as a non-hormonal alternative to HRT in Perimenopausal women - Clinical Pilot Study.

International Journal of Biomedical Science 2006: Vol. 2, No. 2. 143


Femmenessence Menstrual and Reproductive Health

Femmenessence Harmony contains the proprietary ingredient MacaHarmony which is only available in our products. Maca-GO was originally the sole ingredient in Femmenessence MacaHarmony however due to additional research into different maca phenotypes the formulation in Femmenessence MacaHarmony was modified to include 75% Maca-GO and 25% of a proprietary maca phenotype combination focused on focused on fertility, PMS and bone health.

Below is a White Paper summary discussing all of the research in easy to follow terms and goes through the history of our research. This is the ideal first paper to read from the below list:

Article

White Paper – Clinical Effects of a Proprietary, Standardized, Concentrated, Organic Lepidium Peruvianum Formulation (Maca-GO) as an Alternative to HRT by Ronald Carter, M.D.


Revolution MacaLibrium

Please note: The following research articles used various forms and phenotypes of maca. Therefore, consumers may experience different results when using Revolution Macalibrium, which was formulated using specific phenotypes selected for men's health and improved bioavailability.

Article

Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002;34:367.

Gonzales GF, Cordova A, Vega K, et al.

Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. J Endocrinol. 2003;176:163–8.

Gonzales GF, Cordova A, Vega K, et al.

Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men.

Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C.

Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia Asian Journal of Andrology Volume 9 Issue 2 Page 245 - March 2007

Gustavo F. Gonzales, Vanessa Vasquez, Daniella Rodriguez, Carmen Maldonado, Juliet Mormontoy, Jimmy Portella, Monica Pajuelo, León Villegas, Manuel Gasco, P.P. Mathur

Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats 1: Asian J Androl. 2001 Sep;3(3):231-3

G F Gonzales, M Gasco, A Córdova, A Chung, J Rubio and L Villegas

Lepidium meyenii (Maca) improved semen parameters in adult men. Asian J Androl. 2002;3:301–3.

Gonzales GF, Cordova A, Gonzales C, et al.

Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m). J Endocrinol. 2004;180:87–95.Gonzales GF, Gasco M, Cordova A, et al.


Herbatonin

Herbatonin® or plant melatonin has been found in several plants (Dubbels et al., 1995; Hattori et al, 1995). The hormone is also present in algae, where its role may be acting as a phytohormone and anti-oxidant (Balzer and Hardeland, 1996). Amount varies in different species, from 0 to 800 pg/mg protein, with the highest amount found in rice family Gramineae.

The identity of plant melatonin was verified by HPLC. Biological and pharmacological identity with animal melatonin was demonstrated by activity in chicks and rabbits. Dietary (ingested) plant melatonin influences plasma levels and brain receptor binding. Some selected references related to the existence of plant melatonin and the action of Melatonin in in-vivo laboratory models and in humans are included below:

Article

, Huber CG. The role of melatonin in glaucoma: implications concerning pathophysiological relevance and therapeutic potential. J Pineal Res. 2011 Jan;50(1):1-7.

Arendt, J. (1994) Human responses to light and melatonin, pp 439-442 in: "Advances in Pineal Research", Vol 8, Eds: M. Moller and P. Pevet, J. Libbey, London.

Arendt, J. (1995) Significance of melatonin in humans, pp 165-171 in: "The Pineal Gland and its Hormones" Eds: Fraschini, F., Reiter, R.J. and Stankov, B., Plenum Press, New York.

Armstrong, S. M. (1991) Treatment of sleep disorders by melatonin administration, pp 263-274 in: "Advances in Pineal Research," Vol.6, Eds: A. Foldes and R. J. Reiter, John Libbey, London.

, et al. Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. J Matern Fetal Neonatal Med. 2011 May 11. [Epub]

Balzer, I. and Hardeland, R. (1996) Melatonin in algae and higher plants - possible roles as a phytohormone and antioxidant. BotanicaActa 109: 180-183.

Blask, D.E. and Wilson, S.T. (1995) Melatonin action on human breast cancer cells: involvement of glutathione metabolism and the redox environment. pp 209-217 in: "The Pineal Gland and its Hormones" Eds: Fraschini, F., Reiter, R.J. and Stankov, B., Plenum Press, New York.

Cagnoni, M.L., Lombardi, A., Cerinic, M.C., Dedola, G.L. and Pignone, A. (1995) Melatonin for treatment of chronic refractory sarcoidosis, Lancet, 346 (8984): 1229-1230.

Chan, T.Y. and Tang, P.L. (1995) Effect of melatonin on the maintenance of cholesterol homeostasis in the rat, Endocrine Res. 21: 681-696.

Chaste P.et al. Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders. J Pineal Res. 2011 Apr 27. [Epub]

Dubbels, R., Reiter, R.J., Klenke, E., Goebel, A., Schnakenberg, E., Ehlers, C., Schiwara, H.W. and Schloot, W. (1995) Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry, J. Pineal Res. 18: 28-31.

Escames G, et al. The role of mitochondria in brain aging and the effects of melatonin.CurrNeuropharmacol. 2010 Sep;8(3):182-93.

Folkard, S., Arendt, J. and Clark, M. (1993) Can melatonin improve shiftworkers tolerance of the night shift? Some preliminary findings, Quoted in Arendt, J (1994) Human responses to light and melatonin Advances in Pineal Research, Vol 8, Eds: M. Moller and P. Pevet, J. Libbey, London.

, et al. Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study. J Pineal Res. 2007 Nov;43(4):404-9.

Guardiola-Lemaitre, B. (1994) Melatonin agonist/antagonist: from the receptor to therapeutic applications, in: "Advances in Pineal Research", Vol 8, Eds: M. Moller and P. Pevet, pp 333-348, J. Libbey, London.

Hattori, A., Migitaka, H., Iigo, M., Itoh, M., Yamamoto, K., Ohtani-Kaneko, R., Hara, M., Suzuki, T. and Reiter, R.J. (1995) Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates, Biochem. Mol. Biol. Int. 35: 627-634.

Iguchi, H. et al. Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects. The Journal of Clinical Endocrinology& Metabolism. July 1, 1982 vol. 55 no. 1 27-29.

, et al. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res. 1998 Oct;25(3):177-83.

Kaczor, T. An Overview of Melatonin and Breast Cancer. Natural Medicine Journal 2010 Feb.[Epub]

, Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J Pineal Res. 2011 Apr;50(3):261-6. Epub 2010 Dec 8.

Knutsson, A. Health disorders of shift worker. Occupational Medicine 2003;53:103–10

Lewy AJ, Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Chronobiol Int. 2002 May;19(3):649-58.

Lissoni, P., Barni, S., Fossati, V.,Ardizzoia, A., Cazzaniga, M, Tancini, G., and Frigerio, F. (1995) A randomized study of neuroimmunotherapy with low dose subcutaneous interleukin-2 plus melatonin compared to supportive care alone in patients with untreatable metastatic solid tumour, Support Care Cancer, 3: 194-197.

Maestroni, G.J.M., Conti, A. and Covacci, V (1994) pp 73-81 in: "Advances in Pineal Research" vol 7, Eds: Maestroni, G.J.M., Conti, A and Reiter, R.J. John Libbey, London.

, et al. Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry. 2008 Jan;13(1):90-8. Epub 2007 May 15.

Nagtegaal.E., Smits, M., Swart,W., van der Meer, G., and Kerkhof, G.(1995) Melatonin secretion and coronary heart disease, Lancet 346 (8985): 1299.

, Kumar A, SharmaSS.Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades. J Pineal Res. 2011 Mar;50(2):124-31.

Oaknin-Bendahan, S, Anis, Y, Nir, I &Zisapel, N.(1995) Effects of long-term administration of melatonin and a putative antagonist on the ageing rat, Neuroreport, 6: 785-8.

, Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J Pineal Res. 2011 Apr 21. [Epub]

, et al. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res. 2009 Aug;47(1):82-96. Epub 2009 Jun 17.

Parkes, J.D. (1995) Melatonin and sleep, pp 183-198 in: "The Pineal Gland and its Hormones" Eds: Fraschini, F., Reiter, R.J. and Stankov, B., Plenum Press, New York.

Pierpaoli, W., Dall'Ara, A., Pedrinis, E., and Regelson, W. (1991) The pineal control of ageing. The effects of melatonin and pineal grafting on the survival of older mice, Ann. N.Y. Acad. Sci, 621: 291-313.

.Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity.Med Hypotheses. 2011 Jan;76(1):79-85

Robinson, W.A., Dreiling, L., Gonzalez, R. and Balmer, C. (1995) Treatment of human metastatic malignant melanoma with highdose oral melatonin, pp 219-225 in: "The Pineal Gland and its Hormones" Eds: Fraschini, F., Reiter, R.J. and Stankov, B., Plenum Press, New York.

, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011 Apr 19. doi: 10.1111/j.1469-8749.2011.03980.x. [Epub]

, et al. Melatonin in mitochondrial dysfunction and related disorders.Int J Alzheimers Dis. 2011;2011:326320. Epub 2011 May 4.

, The Sleep Disorders Inventory: an instrument for studies of sleep disturbance in persons with Alzheimer's disease.J Sleep Res. 2003 Dec;12(4):331-7.

Vijayalaxmi, Reiter, R.J., Sewerynek, E., Poeggeler, B.. Leal, B.Z. and Meltz, M.L. (1995) Marked reduction of radiation-induced micronucleiin human blood lymphocytes pretreated with melatonin, Radiation Res. 143: 102 - 106.

Wetterberg, L. (1995) Seasonal affective disorder, melatonin and light, pp 199-208 in: "The Pineal Gland and its Hormones" Eds: Fraschini, F., Reiter, R.J. and Stankov, B., Plenum Press, New York.

Zee, PC, Goldstein, CA. Treatment of Shift Work Disorder and Jet Lag.Current Treatment Options in Neurology. 2010; 12:396–411

Zhdanova IV, et al. Melatonin Treatment for Age-Related Insomnia. J ClinEndocrinolMetab, October 2001, 86(10):4727–4730

Zhdanova IV, et al. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J PediatrEndocrinolMetab. 1999 Jan-Feb;12(1):57-67.


pH Quintessence

Below are a list of publications which relate to pH Quintessence:

Article

P. R. Cheeke (1983). Biological Properties and Nutritional Significance of Legume Saponins. Chapter 21, in Leaf Proteins (L. Telek, ed.), A.V.I. Publ. Co., Westport, p.396-414.

H. O. Meissner, R. Carlson and C. Tragardh, (1980). Isolation and purification of proteins from green vegetation for direct human consumption. In: "Food Process Engineering". (P. Linko, Y. Maiki, J. Olkku, Editors) pp. 864-870. Applied Science Publishers Ltd, London.

H. O. Meissner (1989). Commercial Applications of Leaf Protein Research - three faces of industrial leaf fractionation: resources - operation and marketing.. LEAFPRO-89, Pisa, Perugia, Vitterbo-Italy. Italian Journal of Food Science. 1989; p. 360-365.

N.W. Pirie (1987). Leaf Protein and its by-products in human and animal nutrition. London, Cambridge University Press.

H. O. Meissner (1983). Protein Concentrates from Herbage and their Fractionation into Feed- and Food-grade Products. Chapter 15, in: Leaf Proteins (L. Telek, ed.), A.V.I. Publ. Co., Westport, p.437-466.

TGA, Department of Health and Aging, Australian Government. Pure Alfalfa Extract Tablets Medicago sativa (750mg): ARTG registration/listing No: 83132. Supporting evidence for listing of a Therapeutic Preparation. (Canberra, 21 June 2002).