Femmenessence®

MacaLife®

For Perimenopause

120 CAPSULES | 60-Day Supply

4.9/5.0

1 8

Femmenessence®

MacaLife®

For Perimenopause

120 CAPSULES | 60-Day Supply

4.9/5.0

1-Box One-Time Purchase
$36.99
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Femmenessence® MacaLife® is the first natural product to have published double-blind, placebo-controlled human clinical trials demonstrating statistically significant effects on hormones in perimenopausal women. Instead of introducing hormones into the body, Femmenessence nourishes the endocrine system to support the body’s own hormone production.*

Benefits of MacaLife®

  • 74–82% of women reported relief from perimenopausal symptoms within 2 days to 8 weeks (average 21 days).*
  • With personalized support from our Medical Team, success rates increased to 95%.*
  • Supports relief from hot flashes, night sweats, mood fluctuations, sleep changes and energy shifts.*
  • Clinically shown to support hormone balance, heart health, mental well-being and healthy body weight in perimenopausal women.*
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Femmenessence® MacaLife® For Perimenopause
Femmenessence®
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MacaLife®
How It Works Clinical Research Ingredients & Sourcing Community Reviews FAQ
HOW IT WORKS

How Femmenessence® Works to Support Your Hormones, Naturally.

Dr. Deanna Minich, PHD, CNS, IFMCP

Chief Science Officer, Symphony Natural Health

Targets the Root Cause of Perimenopause

During perimenopause, communication between the brain and ovaries becomes less predictable. These fluctuations influence how hormones are produced and balanced, affecting everything from menstrual cycle changes and mood fluctuations to sleep quality and daily energy levels. Femmenessence supports the endocrine system—the HPTAO axis, your body’s hormonal communication network, helping restore the signals that guide hormone balance during perimenopause.*

Supports Your Body’s Own Natural Hormone Production

Instead of introducing synthetic or plant-based hormones, Femmenessence nourishes the body’s natural ability to produce and regulate its own. This means it doesn’t just increase low hormones—it also helps reduce those that are out of balance, supporting your body in finding its optimal rhythm.*

Supports Long-Term Well-Being, Not Just Symptoms

Published clinical research shows Femmenessence® doesn’t just support symptom relief, it also positively impacts key biomarkers related to heart health, mental well-being and overall vitality. By working at the level of the HPTAO axis, Femmenessence supports resilience today and long-term health for the years ahead.*

Delivers Real Results Within 1–2 Boxes

In published, double-blind, placebo-controlled clinical trials, 74–82% of perimenopausal women experienced improvements within 2 days to 8 weeks (average 21 days). When guided by our Medical Team, success rates rose to 95%—with personalized guidance on simple factors like dosage, hydration and nutrition making all the difference.*

From Symptom Relief to Longevity: Hormone Balance is the Key 

Supports Symptom Relief:

Hormone Balance*

Hot Flashes & Night Sweats*

Dryness & Desire*

Mood Swings*

Promotes Longevity:

Heart Health*

Mental Clarity & Focus*

Healthy BMI*

Beauty From The Inside Out:

Hair, Skin & Nail Health*

CLINICAL RESULTS

No More Empty Promises: We Lead with Clinical Evidence and Proof

Most brands talk about balance. Few can prove it. Femmenessence® MacaLife® is one of the few natural products with published, double-blind, placebo-controlled human clinical trials in perimenopausal women–showing statistically significant improvements in hormones, symptoms and overall well-being.*

Kupperman's Index +

The gold standard for measuring perimenopausal well-being—tracking real experiences such as hot flashes, sleep, mood, cycle-related symptoms and energy.*

Kupperman’s Menopausal Index

Perimenopause isn’t just about hormone fluctuations—it’s about how you feel day to day. To measure meaningful change, researchers used the Kupperman Menopausal Index and the Greene Climacteric Scale, two validated tools that evaluate symptoms such as hot flashes, night sweats, sleep quality, mood, nervousness, and overall well-being.* These scales help capture what matters most: women’s actual lived experiences.

In published clinical trials, 74–82% of perimenopausal women reported symptom relief, often within 2 days to 8 weeks, with many noticing improvements around 21 days.*

These symptom changes occurred during the same study period in which women also showed shifts in hormone patterns measured separately in the clinical trial, indicating supportive effects across multiple aspects of perimenopausal well-being.*

Women in the studies commonly reported:

  • Relief from symptoms such as hot flashes, night sweats, and disrupted sleep*
  • More stable mood and emotional well-being*
  • Improved energy, steadiness, and day-to-day vitality*
  • 95% success rate when women were supported by our Medical Team during real-world use*

Placebo crossover design: Women improved on Femmenessence®, worsened on placebo and improved again when switched back—demonstrating a clear product-related effect*

Publication: 

Estradiol +

Estradiol is the primary form of estrogen—key for temperature regulation, mood, sleep, and menstrual cycle patterns. During perimenopause, estradiol levels fluctuate dramatically, contributing to many of the symptoms women commonly experience.*

Estradiol

Estradiol is one of the most important hormones for women’s health.

During perimenopause, estradiol levels may rise and fall unpredictably, which can lead to hot flashes, night sweats, sleep disruption, mood changes and irregular menstrual cycles.

In published double-blind, placebo-controlled clinical trials on perimenopausal women, those taking Femmenessence® MacaLife® experienced a statistically significant increase in estradiol, while the placebo group showed no meaningful change.*

This hormonal shift occurred during the same study period in which women also reported improvements in perimenopausal symptoms, as measured separately using validated symptom scales, indicating supportive effects across multiple aspects of well-being.*

Women in the studies commonly reported:

  • Fewer hot flashes and night sweats*
  • More stable mood and emotional well-being*
  • Improved sleep quality and reduced nervousness*

By supporting the body's natural ability to regulate estradiol—rather than adding plant or synthetic hormones—Femmenessence® MacaLife® helps support healthier hormonal communication during perimenopause.*

Publication: 

Progesterone +

Progesterone plays a key role in emotional steadiness, sleep quality, and menstrual cycle patterns. During perimenopause, levels often change earlier and more sharply than estradiol, contributing to many of the shifts women notice at this stage.*

Progesterone

Progesterone is one of the body’s primary calming and coordinating hormones.

As women move through perimenopause, progesterone levels can become lower or more irregular, which may be associated with mood changes, disrupted sleep and menstrual cycles that feel less predictable.*

In published double-blind, placebo-controlled clinical trials on perimenopausal women, those taking Femmenessence® MacaLife® experienced a statistically significant increase in progesterone, while women in the placebo group showed no meaningful change.*

This hormonal shift occurred during the same study period in which women also reported improvements in perimenopausal symptoms, as measured separately using validated symptom scales, suggesting supportive effects across both hormone patterns and day-to-day well-being.*

Women in the studies commonly reported:

  • Improved sleep quality and fewer nighttime disruptions*
  • More stable mood and emotional well-being*
  • Feeling more supported through the ups and downs of perimenopause*

By supporting the body’s natural ability to regulate progesterone—rather than adding plant or synthetic hormones—Femmenessence® MacaLife® helps support healthier hormonal communication during perimenopause.*

Publication: 

Heart Health +

During perimenopause, natural hormonal shifts can influence cholesterol, triglycerides and other markers related to cardiovascular well-being.*

Heart Health

Hormonal fluctuations during perimenopause affect more than hot flashes or menstrual patterns—they can also influence how the body manages cholesterol, triglycerides and circulation. These changes can contribute to shifts in cardiovascular markers over time.

In published double-blind, placebo-controlled clinical trials, perimenopausal women taking Femmenessence® MacaLife® showed favorable changes in cardiovascular markers, including:

  • Higher HDL (“good”) cholesterol*
  • Lower LDL cholesterol*
  • Reduced triglycerides*
  • Positive trends in blood pressure markers*

These findings occurred during the same study period in which women also reported improvements in perimenopausal symptoms, suggesting supportive effects across multiple systems involved in well-being.*

By supporting hormone balance at the source, Femmenessence® MacaLife® helps maintain healthy communication within the endocrine system—supporting circulation, energy and whole-body vitality during perimenopause.*

Publication: 

Mental & Emotional Health +

Hormonal shifts during perimenopause can influence how women feel emotionally and mentally—affecting mood, clarity and overall sense of steadiness.*

Mental & Emotional Health

Perimenopause affects more than physical symptoms. As estradiol and progesterone fluctuate, many women notice changes in mood, emotional steadiness, sleep patterns, and mental clarity. Because these experiences are so central to daily life, researchers evaluated emotional well-being using validated symptom scales.

In published, double-blind, placebo-controlled clinical trials, perimenopausal women taking Femmenessence® MacaLife® reported statistically significant improvements in mood, emotional well-being, and overall vitality compared with placebo. Women also described clearer thinking and better sleep quality during the study period.*

Beyond hormonal support, Femmenessence® MacaPause® contains a natural spectrum of amino acids and plant compounds—including macamides, macaenes and glucosinolates—unique secondary metabolites that contribute to Femmenessence’s distinctive nutritional profile and are part of the broader whole-root matrix that helps maintain healthy communication throughout the body.*

These improvements in emotional and mental well-being occurred during the same study period in which women also experienced favorable changes in hormone patterns, as measured separately, reflecting supportive effects across multiple aspects of perimenopausal health.*

Women in the studies commonly reported:

  • More stable mood and emotional steadiness*
  • Improved sleep quality*
  • Clearer thinking and better daytime energy*
  • A greater sense of balance during daily life*

By supporting the body’s natural hormonal communication—not by adding hormones—Femmenessence® MacaLife® helps women feel more grounded and supported through the mental and emotional changes of perimenopause.*

Publication: 

Hair, Skin & Nail Health +

Hormonal changes during perimenopause can influence visible aspects of well-being—including the appearance of hair, skin and nails.*

Hair, Skin & Nail Health

Perimenopause isn’t just something women feel internally—it often shows externally too. As estradiol and progesterone fluctuate, many women notice changes in the appearance of their hair, skin, and nails. Because these visible signs are so closely tied to confidence and everyday well-being, researchers evaluated them as part of the clinical trial.

In published double-blind, placebo-controlled clinical research, perimenopausal women taking Femmenessence® MacaLife® reported improvements in hair thickness, skin vitality and nail strength, compared to baseline. Women reported healthier-looking skin, stronger nails and improvements in hair appearance during the study period.*

These visible changes occurred during the same research period in which women also showed shifts in hormone patterns measured separately, reflecting the broader whole-body support observed in the trial.*

Women in the studies commonly reported:

  • Healthier-looking skin with improved vitality*
  • Thicker-feeling or more resilient hair*
  • Stronger-feeling nails*
  • A renewed sense of outer and inner well-being*

By supporting the body’s natural hormonal communication, Femmenessence® MacaLife® helps maintain the internal balance that influences visible vitality during perimenopause.*

Publication: 

Learn More

Kupperman’s Menopausal Index

Perimenopause isn’t just about hormone fluctuations—it’s about how you feel day to day. To measure meaningful change, researchers used the Kupperman Menopausal Index and the Greene Climacteric Scale, two validated tools that evaluate symptoms such as hot flashes, night sweats, sleep quality, mood, nervousness, and overall well-being.* These scales help capture what matters most: women’s actual lived experiences.

In published clinical trials, 74–82% of perimenopausal women reported symptom relief, often within 2 days to 8 weeks, with many noticing improvements around 21 days.*

These symptom changes occurred during the same study period in which women also showed shifts in hormone patterns measured separately in the clinical trial, indicating supportive effects across multiple aspects of perimenopausal well-being.*

Women in the studies commonly reported:

  • Relief from symptoms such as hot flashes, night sweats, and disrupted sleep*
  • More stable mood and emotional well-being*
  • Improved energy, steadiness, and day-to-day vitality*
  • 95% success rate when women were supported by our Medical Team during real-world use*

Placebo crossover design: Women improved on Femmenessence®, worsened on placebo and improved again when switched back—demonstrating a clear product-related effect*

Publication: 

Estradiol

Estradiol is one of the most important hormones for women’s health.

During perimenopause, estradiol levels may rise and fall unpredictably, which can lead to hot flashes, night sweats, sleep disruption, mood changes and irregular menstrual cycles.

In published double-blind, placebo-controlled clinical trials on perimenopausal women, those taking Femmenessence® MacaLife® experienced a statistically significant increase in estradiol, while the placebo group showed no meaningful change.*

This hormonal shift occurred during the same study period in which women also reported improvements in perimenopausal symptoms, as measured separately using validated symptom scales, indicating supportive effects across multiple aspects of well-being.*

Women in the studies commonly reported:

  • Fewer hot flashes and night sweats*
  • More stable mood and emotional well-being*
  • Improved sleep quality and reduced nervousness*

By supporting the body's natural ability to regulate estradiol—rather than adding plant or synthetic hormones—Femmenessence® MacaLife® helps support healthier hormonal communication during perimenopause.*

Publication: 

Progesterone

Progesterone is one of the body’s primary calming and coordinating hormones.

As women move through perimenopause, progesterone levels can become lower or more irregular, which may be associated with mood changes, disrupted sleep and menstrual cycles that feel less predictable.*

In published double-blind, placebo-controlled clinical trials on perimenopausal women, those taking Femmenessence® MacaLife® experienced a statistically significant increase in progesterone, while women in the placebo group showed no meaningful change.*

This hormonal shift occurred during the same study period in which women also reported improvements in perimenopausal symptoms, as measured separately using validated symptom scales, suggesting supportive effects across both hormone patterns and day-to-day well-being.*

Women in the studies commonly reported:

  • Improved sleep quality and fewer nighttime disruptions*
  • More stable mood and emotional well-being*
  • Feeling more supported through the ups and downs of perimenopause*

By supporting the body’s natural ability to regulate progesterone—rather than adding plant or synthetic hormones—Femmenessence® MacaLife® helps support healthier hormonal communication during perimenopause.*

Publication: 

Heart Health

Hormonal fluctuations during perimenopause affect more than hot flashes or menstrual patterns—they can also influence how the body manages cholesterol, triglycerides and circulation. These changes can contribute to shifts in cardiovascular markers over time.

In published double-blind, placebo-controlled clinical trials, perimenopausal women taking Femmenessence® MacaLife® showed favorable changes in cardiovascular markers, including:

  • Higher HDL (“good”) cholesterol*
  • Lower LDL cholesterol*
  • Reduced triglycerides*
  • Positive trends in blood pressure markers*

These findings occurred during the same study period in which women also reported improvements in perimenopausal symptoms, suggesting supportive effects across multiple systems involved in well-being.*

By supporting hormone balance at the source, Femmenessence® MacaLife® helps maintain healthy communication within the endocrine system—supporting circulation, energy and whole-body vitality during perimenopause.*

Publication: 

Mental & Emotional Health

Perimenopause affects more than physical symptoms. As estradiol and progesterone fluctuate, many women notice changes in mood, emotional steadiness, sleep patterns, and mental clarity. Because these experiences are so central to daily life, researchers evaluated emotional well-being using validated symptom scales.

In published, double-blind, placebo-controlled clinical trials, perimenopausal women taking Femmenessence® MacaLife® reported statistically significant improvements in mood, emotional well-being, and overall vitality compared with placebo. Women also described clearer thinking and better sleep quality during the study period.*

Beyond hormonal support, Femmenessence® MacaPause® contains a natural spectrum of amino acids and plant compounds—including macamides, macaenes and glucosinolates—unique secondary metabolites that contribute to Femmenessence’s distinctive nutritional profile and are part of the broader whole-root matrix that helps maintain healthy communication throughout the body.*

These improvements in emotional and mental well-being occurred during the same study period in which women also experienced favorable changes in hormone patterns, as measured separately, reflecting supportive effects across multiple aspects of perimenopausal health.*

Women in the studies commonly reported:

  • More stable mood and emotional steadiness*
  • Improved sleep quality*
  • Clearer thinking and better daytime energy*
  • A greater sense of balance during daily life*

By supporting the body’s natural hormonal communication—not by adding hormones—Femmenessence® MacaLife® helps women feel more grounded and supported through the mental and emotional changes of perimenopause.*

Publication: 

Hair, Skin & Nail Health

Perimenopause isn’t just something women feel internally—it often shows externally too. As estradiol and progesterone fluctuate, many women notice changes in the appearance of their hair, skin, and nails. Because these visible signs are so closely tied to confidence and everyday well-being, researchers evaluated them as part of the clinical trial.

In published double-blind, placebo-controlled clinical research, perimenopausal women taking Femmenessence® MacaLife® reported improvements in hair thickness, skin vitality and nail strength, compared to baseline. Women reported healthier-looking skin, stronger nails and improvements in hair appearance during the study period.*

These visible changes occurred during the same research period in which women also showed shifts in hormone patterns measured separately, reflecting the broader whole-body support observed in the trial.*

Women in the studies commonly reported:

  • Healthier-looking skin with improved vitality*
  • Thicker-feeling or more resilient hair*
  • Stronger-feeling nails*
  • A renewed sense of outer and inner well-being*

By supporting the body’s natural hormonal communication, Femmenessence® MacaLife® helps maintain the internal balance that influences visible vitality during perimenopause.*

Publication: 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

USDA Organic Vegan Kosher 3rd-Party Tested Gluten, Soy, Dairy, Allergen-Free No Fillers, Additives, Preservative

INGREDIENTS AND SOURCING

Femmenessence: Where Science Meets Intention

Every step of Femmenessence®—from the soil where our maca is grown to create Maca-GO® to the science that validates our formulation—is guided by one purpose: to support women’s hormonal health naturally and effectively. Rooted in integrity and backed by clinical research, this is where nature’s intelligence and human intention come together to create a real, measurable difference.

Life-Stage-Specific
Proprietary Formulation

Not all maca is the same. There are 17 distinct types–called phenotypes–that can have different DNA, nutrient profiles and physiological effects. Maca-GO®, a proprietary combination of phenotypes used in Femmenessence® MacaLife®, is formulated in precise ratios for perimenopausal women.

Trusted by the World’s Leading Experts in Women’s Health

Developed over more than a decade of research, Femmenessence® is one of the few natural products with double-blind, placebo-controlled human clinical trials published in respected medical journals. In perimenopausal women, these trials showed statistically significant changes in key hormone markers, along with improvements in symptoms and overall well-being.*

Trusted by the World’s Leading Experts in Women’s Health

For more than 18 years, health practitioners around the world have recommended Femmenessence® to their patients, recognizing its scientific credibility and clinical support for hormonal balance.*

Vertical Integration: Ensuring Quality from Seed to Soul

We oversee every step of the journey—from high-altitude farming to formulation, research and final packaging. This vertical integration helps ensure purity, potency and consistency in every capsule, upholding our commitment to supporting women’s health at every stage.*

Not All Maca Is Created Equal

Why Our Maca Is Different

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For centuries, maca has been known in the Andes as a sacred root—cultivated where intense sun, thin air and freezing nights shaped a plant unlike any other. Used by Indigenous communities for more than 2,000 years, maca was valued for nourishment, vitality and resilience.

But not all maca is the same. There are 17 distinct types—called phenotypes—that differ in DNA, color and active compounds, producing different effects on the body. Most maca on the market combines these types randomly, which can make them ineffective or even worsen symptoms.*

Femmenessence® MacaLife® contains Maca-GO®—a proprietary, life-stage-specific combination of phenotypes developed by Symphony Natural Health after more than a decade of research.

Femmenessence® is the only formulation with published, double-blind, placebo-controlled clinical trials demonstrating statistically significant effects on key hormones in postmenopausal and perimenopausal women.

Every maca phenotype contains a unique profile of amino acids, vitamins and minerals that support hormone-producing glands.

Femmenessence® delivers a full amino acid profile—the essential building blocks for hormones and neurotransmitters—with a nutrient density that exceeds that of leading maca extracts in both the U.S. and Europe.*

The chart below shows a comparative amino acid chromatogram of Femmenessence [1 & 6] vs. other leading maca extracts [3 & 4].

Why Our Maca Is Different

From the Andes: Where It’s Grown & Why It Matters

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True maca grows only at extreme altitudes, between 11,500 and 16,400 feet in the central highlands of Peru. The harsh conditions and mineral-rich volcanic soil allow the plant to develop its full spectrum of bioactive compounds.

We partner directly with local farming communities, honoring traditional organic practices that preserve both the land and cultural heritage:

  • Crops are rotated every 5–7 years.
  • Roots are hand-harvested and sun-dried at altitude.
  • No chemical fertilizers or solvents are ever used.

This commitment sustains the potency of our raw materials and the integrity of the communities that cultivate them.

Precision Processing: From Roots to Results

+

The maca used to create Maca-GO® undergoes a proprietary, solvent-free process that uses only water, temperature and pressure—never chemicals—to concentrate and stabilize the active ingredients.

This process optimizes bioavailability (up to 99%), allowing the body to utilize beneficial compounds efficiently.

Each batch is standardized for potency and consistency—so every capsule delivers the same profile studied in our clinical trials.*

Glucosinolates—compounds also found in cruciferous vegetables—play a critical role in hormone metabolism and detoxification. They’re sensitive to heat and oxidation, which is why our solvent-free process is so important. Femmenessence® preserves high levels of glucosinolates—up to 400x those found in broccoli and Brussels sprouts—maintaining the bioactive compounds your body needs for hormonal communication and balance.

The chart below compares glucosinolate concentrations in Femmenessence with those in other maca extracts.

Precision Processing: From Roots to Results

Purity You Can Trust

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Every capsule of Femmenessence® MacaLife® is:

  • USDA Organic, Non-GMO and Vegan
  • Free from fillers, preservatives, gluten, soy, dairy and corn
  • Third-party tested for heavy metals, purity and safety

From soil to supplement, we uphold the highest standards to ensure purity, potency and transparency—because integrity is part of every step we take.

Clinically Studied. Practitioner Trusted.

+

Unlike many natural products that rely on generic ingredient research, Femmenessence® MacaLife® is the exact formulation used in published, double-blind, placebo-controlled human clinical trials.

Our double-blind, placebo-controlled human clinical trials have been published in respected international medical journals and presented to leading organizations, including the North American Menopause Society (NAMS) and the American College of Obstetricians and Gynecologists (ACOG).

That’s why Femmenessence® is trusted by physicians, naturopaths and integrative health experts around the world.

The Symphony Natural Health Difference

+

We call our approach Seed to Soul. We don’t just cultivate the maca used to create our formulations—we research it, transform it, standardize it and verify every batch.

By overseeing each stage from cultivation to packaging, we ensure unmatched purity, potency and consistency, from the highlands of Peru to your hands.

All to support women’s hormonal health and whole-person well-being—physical, emotional, mental and spiritual.

Available at these grocers and wellness centers

From our Community

Customer Reviews

  • Healthcare Provider

    "To me, health is more than the absence of disease. It’s the vibrant spectrum of physical, emotional, mental, and spiritual aspects that work together like a symphony. Femmenessence allows for this whole-self integration by nourishing the endocrine system. As I go through the journey of perimenopause, I am grateful to be able to bring in the innate wisdom of plants to naturally allow my own inner wisdom to express!"

    Dr. Deanna Minich PhD, CNS, FACN, IFMCP

  • Healthcare Provider

    "I have used Femmenessence for 8 years in my women's health practice. It has become a mainstay botanical approach for my peri- and postmenopausal patients. I also often use Femmenessence for added heart and bone health support. I am a big advocate of Femmenessence, as it has given me a tool I didn't have to help me, help more women.*"

    Kathryn Landherr M.D., OB/GYN

  • Healthcare Provider

    "Before I recommend hormones or herbs, I begin the process of supporting a patient’s hormonal balance with Femmenessence. In conjunction with lifestyle modification, this plant-based intervention serves to re-educate the complex feedback loops between her brain and endocrine system. In this way, we are leveraging the power of natural medicine to heal. In 6 years of clinical use of this product, the results, within two cycles, remain astounding."

    Kelly Brogan M.D.

  • Healthcare Provider

    "It’s a rare occurrence in medicine when you can find a non-prescription supplement that helps women to the point where it becomes one of your primary go-to’s for hormone health. I have wholeheartedly endorsed Femmenessence® for the past 6 years, not just because of their mission statement and desire to help women, but also because of the research, time, care, foundations and scientific evidence they’ve invested in improving women’s health. I highly encourage every one of my patients, whether they’re pre-menopausal or menopausal or even those with PMS, irregular periods, and other hormonal imbalances, to try Femmenessence."

    Shawn Tassone M.D., OB/GYN
Frequently Asked Questions

Questions About Femmenessence® MacaLife®?
We’re Here to Help

How is Femmenessence® MacaLife® different from other perimenopause supplements?

+

Most perimenopause supplements add hormones (synthetic or plant-based) or rely on generic maca powders that have never been clinically tested in the women they’re intended for.

Femmenessence® is different.

Femmenessence is the first natural product with published double-blind, placebo-controlled human clinical trials showing statistically significant changes in key hormones in both peri- and postmenopausal women.*

MacaLife® uses the same scientific approach: a proprietary, phenotype-specific formulation crafted for the unique hormonal patterns of perimenopause. Instead of adding hormones, Femmenessence supports the body’s own hormone production and communication, addressing the root cause of perimenopausal shifts.*

This combination of life-stage targeting, clinical research and real-world results is what makes Femmenessence stand apart.

How long will it take before I notice results?

+

In published clinical trials, 74–82% of perimenopausal women reported improvements in symptoms within 2 days to 8 weeks, with many noticing changes around 21 days (one box).*

Because perimenopause is a dynamic transition, every woman’s experience is unique. Some notice shifts quickly, while others may need more time as their endocrine system adapts to changing hormone patterns.

Factors such as stress levels, sleep, hydration, dose timing, and overall health history can all influence how quickly your body responds.

Many women continue to see deeper, more consistent benefits over several cycles, and our Medical Team is always available to help personalize your approach for the best results.*

What symptoms can MacaLife® help support?

+

In published clinical research on perimenopausal women, Femmenessence® MacaLife® supported improvements in:*

  • Hot flashes & night sweats*
  • Sleep quality and restfulness*
  • Mood fluctuations & emotional steadiness*
  • Energy and daily vitality*
  • Cycle-related changes and irregularities*
  • Occasional anxiousness and stress*
  • Cognitive clarity*

Clinical trials also showed statistically significant support for estradiol, progesterone, and broader endocrine communication, as well as positive shifts in cardiovascular and metabolic wellness markers—all important during perimenopause.*

Is MacaLife® safe to take with other medications?

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In most cases, Femmenessence® can be taken alongside supplements or over-the-counter medications. To support optimal absorption, we recommend taking MacaLife® at least one hour apart from other supplements or medications.

Because every woman’s perimenopause experience and health history is unique, it’s always best to consult your healthcare provider before beginning any new supplement.

As a precaution, Femmenessence should not be used with:

  • Tamoxifen
  • Hormone-suppressing medications

Our Medical Team is available if you have questions about how to incorporate MacaLife® into your current routine or need personalized guidance.*

Do I need to take MacaLife® forever?

+

Not necessarily. Most women take the full serving for 6–9 months, then transition to a maintenance dose as their perimenopause patterns stabilize.

Because perimenopause can last several years and hormone patterns continue to shift, many women choose to maintain ongoing support through this transition.*

You can also adjust your routine over time. Our Medical Team is available to help personalize your approach based on your symptoms, cycle patterns, and health goals.*

What makes MacaLife® clinically proven?

+

Femmenessence® MacaLife® is one of the few natural products with double-blind, placebo-controlled human clinical trials conducted on the actual formulation you’re taking—specifically in perimenopausal women.

Published research demonstrated statistically significant support for key hormone markers, including estradiol and progesterone, as well as improvements in validated symptom scores (74–82% of women). Studies also showed benefits for cardiovascular markers, metabolic wellness, and overall quality of life during perimenopause.*

This combination of formulation-specific research, life-stage targeting, and published results makes MacaLife® uniquely credible in the perimenopause space.*

How do I take MacaLife®?

+

Take 1 capsule, twice daily with 8–16 oz. of water, ideally before or between meals.

  • Take the first capsule in the morning
  • Take the second capsule in the afternoon, ideally 30 minutes before your typical low-energy time

Not to be taken in conjunction with hormone-suppressing medications such as Tamoxifen. 

Not to be taken if nursing or past the second trimester of pregnancy, unless advised by your healthcare professional. 

Please consult your healthcare provider before starting Femmenessence if you are taking any medications.

Our Medical Team is always available to help tailor your routine.*

What if MacaLife® doesn’t work for me?

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Perimenopause is a constantly shifting transition, and women respond at different speeds. Some notice improvements quickly, while others may need several weeks or cycles as their hormone patterns begin to rebalance.

If you’re not seeing changes right away, our Medical Team can help fine-tune your routine. Adjusting factors such as hydration, dose timing, consistency, and simple lifestyle elements often helps women achieve better results.

With Medical Team support, success rates have reached up to 95%, especially when women receive guidance tailored to their personal hormone patterns.*

You don’t have to navigate perimenopause alone — we’re here to support you.

Will Femmenessence® MacaLife® upset my digestive system?

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Most women tolerate MacaLife® well. Occasionally, during the early stages of perimenopause support, some may experience mild digestive changes as their body adjusts.

If this happens, you can try:

  • Reducing your serving size by half until symptoms subside
  • Taking MacaLife® with food for the first 7–10 days, then returning to between-meal timing
  • Adding a probiotic to support digestion
  • Incorporating Sole therapy to support hydration and nutrient absorption

These adjustments often help ease the transition. And if you’d like guidance tailored to your perimenopause symptoms, our Medical Team is available to help.*

OUR MEDICAL TEAM

World-Class Leaders in Women's Health—Here For You

Our medical team is different. With over 200 years of combined clinical experience—treating more than 150,000 women just like you—they're the experts other doctors turn to for continuing education and guidance. At Symphony Natural Health, they're not just figureheads. They create trusted health resources and provide personal support seven days a week. Most importantly, they're your partners in health—bringing the expertise, compassion and guidance you can count on every step of the way.

Jan Roberts

Jan Roberts

Pharmacist & Clinical Nutritionist

Dr. Mona Fahoum

Dr. Mona Fahoum

Naturopathic Doctor

Dr. Wendy Warner

Dr. Wendy Warner

MD & OBGYN

Dr. Deanna Minich

Dr. Deanna Minich

Ph.D

Dr. Tori Hudson

Dr. Tori Hudson

Naturopathic Doctor

Dr. Kim Ross

Dr. Kim Ross

Doctor in Clinical Nutrition

Dr. Corey Schuler

Dr. Corey Schuler

Nurse Practitioner & D.C.

Dr. Marc Sklar

Dr. Marc Sklar

L.Ac & Fertility Expert

Learn More About Our Medical Team
FROM HORMONAL HEALTH TO WHOLE HEALTH

Perimenopause Health Hub

Most health content is one-size-fits-all. Ours isn’t. Here you’ll find life-stage-specific guidance created and curated by our medical team for your perimenopause health. More than articles, this space offers trusted answers, expert insights, and whole-health support on topics from menstrual cycle changes and sleep shifts to mood, energy and daily well-being—so you can feel informed, connected and supported through every transition.

PERIMENOPAUSE HEALTH RESOURCES

Menopause Redefined: A Holistic Approach to Hormones and Wellness

BLOG — JAN ROBERTS

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Find Hormonal Harmony Naturally

BLOG - SYMPHONY NATURAL HEALTH MEDICAL TEAM

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The Whole Health Guide to Heart Health

GUIDE — THE MEDICAL TEAM

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MORE FROM SYMPHONY NATURAL HEALTH

Beyond Hormone Balance: Support for the Whole You

Your journey doesn’t stop at hormonal balance—it begins there. These Symphony Natural Health products were carefully selected to complement Femmenessence®—supporting restful sleep, gentle detoxification and healthy hydration, three areas often affected by hormonal shifts. Together, they help restore balance where your body needs it most—so you can feel rested, replenished and re-energized every day.*

Herbatonin® 0.3 mg

Hormonal shifts can disrupt more than balance–they can affect sleep, recovery and energy.

Herbatonin® 0.3 mg is the world’s first phyto-melatonin–a 100% plant-based extract from alfalfa, chlorella and rice that supports natural circadian rhythm, antioxidant protection and cellular health.*

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Herbatonin® 0.3 mg

Plant-Based Melatonin

pH Quintessence

Hormonal changes can make it harder for your body to stay balanced.


pH Quintessence is a 40:1 Alfalfa concentrate rich in chlorophyll, antioxidants, vitamins, minerals and essential amino acids, that helps alkalize the body by balancing pH and supporting detox and the metabolism of hormones.*

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pH Quintessence

Detoxification Support

Sole Jar Plus Stones product glass jar filled with water and Himalayan Crystal Salt stones with cork cover and tan product box both featuring Himalayan Crystal Salt logo, and wooden spoon, on white background

Hydration isn’t just about drinking more water—it’s about how well your cells absorb it. 

Sole, a mineral-rich Himalayan salt solution, helps support hydration, an essential foundation for hormone balance and overall health.* 

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Original Himalayan Crystal Salt®

Sole Jar Plus Stones

JOIn THE FEMMENESSENCE COMMUNITY

Follow us @Femmenessence

JOIN THE MOVEMENT

Bringing Feminine Consciousness To Balance in

For too long, society has moved out of balance—elevating the masculine while neglecting the feminine. The Femmenessence Movement seeks to restore balance by honoring the feminine consciousness within us all, creating a society that is more connected, compassionate, and caring. Beyond health, it’s about reshaping how we lead, learn and live—to create a brighter now and a more balanced future for generations to come.

Thank you for joining our movement!